RNA Editing in Hepatitis Delta Virus: Unsolved Puzzles
نویسندگان
چکیده
منابع مشابه
RNA editing in hepatitis delta virus.
Hepatitis delta virus (HDV) relies heavily on host functions and on structural features of the viral RNA. A good example of this reliance is found in the process known as HDV RNA editing, which requires particular structural features in the HDV antigenome, and a host RNA editing enzyme, ADAR1. During replication, the adenosine at the amber/W site in the HDV antigenome is edited to inosine. As a...
متن کاملRNA editing in hepatitis delta virus
.............................................................................................iii List of abbreviations...............................................................................v Introduction...........................................................................................1 Results: Part A.................................................................................
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The hepatitis delta virus genome is a small circular RNA, similar to viroids. Although HDV contains a gene, the protein produced (HDAg) is encoded by less than half the genome and possesses no RNA polymerase activity. Because of this limited coding capacity, HDV relies heavily on host functions and on structural features of the viral RNA-very much like viroids. The virus' use of host RNA editin...
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During the replication cycle of hepatitis delta virus (HDV), RNA editing occurs at position 1012 on the 1679-nucleotide RNA genome. This changes an A to G in the amber termination codon, UAG, of the small form of the delta antigen (delta Ag). The resultant UGG codon, tryptophan, allows the translation of a larger form of the delta Ag with a 19-amino-acid C-terminal extension. Using HDV cDNA-tra...
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RNA editing at the amber/W site plays a central role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produce two functionally distinct forms of the sole viral protein, hepatitis delta antigen (HDAg), from the same open reading frame. Editing is carried out by a cellular activity known as ADAR (adenosine deaminase), which acts on RNA substrates that are at least p...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2004
ISSN: 1537-744X
DOI: 10.1100/tsw.2004.123